Abstract | INTRODUCTION: METHODS: We retrospectively reviewed medical charts of patients with severe BPD who were ventilator dependent at home. We excluded patients with other comorbidities that could contribute to the severity of BPD. Spirometry was performed when the patient was able to follow commands. RESULTS: Between 1984 and 2012, within our severe BPD cohort who previously required home ventilator support, 19 patients were able to perform reproducible spirometry meeting ATS/ERS acceptability criteria. Ten (52.6%) were females, 13 (68.4%) were Caucasians. Mean age at liberation from ventilation was 2.4 years (C.I. 2.0, 2.9) and at decannulation was 3.5 years (C.I. 2.9, 4.0); median age at first reproducible spirometry measurement was 6.6 years (IQR: 4.9, 8.3). Spirometry results revealed significant airway obstruction, as demonstrated by Z-scores values of -1.5 (C.I. -2.5, -0.4) for FVC, -2.7 (C.I. -3.3, -1.9) for FEV1 , and -3.6 (C.I. -4.3, -2.9) for FEF25-75 . More so, serial spirometric measurements' slopes revealed that the airway obstruction remained static over time (FEV1 slope: -0.07, P-value: 0.2624; FVC slope: -0.01, P-value: 0.9064; and FEF25-75 : 0.0, P-value: 0.8532). CONCLUSIONS: Extreme prematurity associated with severe BPD requiring home ventilator support carries significant risks of morbidity. These patients had substantially diminished respiratory function reflecting airflow abnormalities that remained static over time.
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Authors | A Ioana Cristea, Veda L Ackerman, Nancy L Swigonski, Zhangsheng Yu, James E Slaven, Stephanie D Davis |
Journal | Pediatric pulmonology
(Pediatr Pulmonol)
Vol. 50
Issue 11
Pg. 1113-8
(Nov 2015)
ISSN: 1099-0496 [Electronic] United States |
PMID | 26479734
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | © 2014 Wiley Periodicals, Inc. |
Topics |
- Airway Obstruction
(etiology, physiopathology)
- Bronchopulmonary Dysplasia
(complications, physiopathology, therapy)
- Child, Preschool
- Chronic Disease
- Female
- Humans
- Infant, Newborn
- Infant, Premature
- Infant, Very Low Birth Weight
- Male
- Pregnancy
- Respiration
- Respiratory Insufficiency
(complications, physiopathology, therapy)
- Retrospective Studies
- Spirometry
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