Abstract | OBJECTIVE: METHODS: For this systematic review comparing tranylcypromine with placebo or active comparators in bipolar depression, relevant randomized controlled trials were identified from systematic searches of PubMed, EMBASE, and Cochrane library databases. A manual search of the references of the included studies was also performed. RESULTS: Four studies with a total of 145 participants were identified. Response rates were higher in patients treated with tranylcypromine (60.0%-80.7%; overall response rate, 73.7%) compared with placebo, imipramine, and lamotrigine (the latter as add-on to a mood stabilizer) (12.9%-47.6%; overall response rate, 27.5%). The overall switch rate was 6.3% for patients treated with tranylcypromine and 18.4% for patients in the control group. CONCLUSIONS:
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Authors | Willemijn T Heijnen, Jürgen De Fruyt, André I Wierdsma, Pascal Sienaert, Tom K Birkenhäger |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 35
Issue 6
Pg. 700-5
(Dec 2015)
ISSN: 1533-712X [Electronic] United States |
PMID | 26479223
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Monoamine Oxidase Inhibitors
- Tranylcypromine
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Topics |
- Adult
- Bipolar Disorder
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Monoamine Oxidase Inhibitors
(adverse effects, pharmacology)
- Tranylcypromine
(adverse effects, pharmacology)
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