Abstract | PURPOSE: To clarify the antimicrobial efficacy of zinc chloride (ZnCl2) and cetylpyridinium chloride ( CPC) by testing their impact on the growth of seven bacterial strains known to be involved in the pathophysiology of both peri-implant disease and halitosis-Staphylococcus aureus, Streptococcus mutans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Treponema denticola, and Tannerella forsythia. MATERIALS AND METHODS: A time-response growth curve was obtained. Commercial mouthrinses with CPC, ZnCl2, or both were added to the media in a final concentration of 0.25% CPC, 2.5% ZnCl2, and 2.5% ZnCl2 with 0.25% CPC. RESULTS: Both CPC and ZnCl2 effectively inhibited the growth of almost all bacterial strains tested except T denticola. ZnCl2 was generally more effective in suppressing bacterial growth than CPC. ZnCl2 with CPC showed the greatest inhibitory activities on almost all strains of bacterial growth except for P gingivalis and T denticola, followed by ZnCl2, then CPC, thus suggesting the possibility of a synergistic effect of the two agents. P gingivalis exhibited a different pattern because ZnCl2 showed the most significant inhibitory effect. CPC did not show growth inhibitory effects on T denticola, but ZnCl2 did. CONCLUSION:
Zinc and CPC effectively inhibit bacterial growth that causes both halitosis and peri-implant disease. The effect is even more powerful when applied in combination.
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Authors | Jeong Hyun Kang, Yun Ji Jang, Dae Jeong Kim, Ji Woon Park |
Journal | The International journal of oral & maxillofacial implants
(Int J Oral Maxillofac Implants)
2015 Nov-Dec
Vol. 30
Issue 6
Pg. 1341-7
ISSN: 1942-4434 [Electronic] United States |
PMID | 26478974
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Chlorides
- Dental Implants
- Drug Combinations
- Mouthwashes
- Zinc Compounds
- zinc chloride
- Cetylpyridinium
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Topics |
- Anti-Bacterial Agents
(administration & dosage, pharmacology)
- Bacteroides
(drug effects)
- Cetylpyridinium
(administration & dosage, pharmacology)
- Chlorides
(administration & dosage, pharmacology)
- Dental Implants
(microbiology)
- Drug Combinations
- Fusobacterium nucleatum
(drug effects)
- Halitosis
(microbiology)
- Humans
- Materials Testing
- Mouthwashes
(administration & dosage, pharmacology)
- Peri-Implantitis
(microbiology)
- Porphyromonas gingivalis
(drug effects)
- Prevotella intermedia
(drug effects)
- Staphylococcus aureus
(drug effects)
- Stomatitis
(microbiology)
- Streptococcus mutans
(drug effects)
- Treponema denticola
(drug effects)
- Zinc Compounds
(administration & dosage, pharmacology)
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