Bioactive glasses (BGs) are known to bond to both hard and soft tissues. Upon exposure to an aqueous environment, BG undergoes ion exchange, hydrolysis, selective dissolution and precipitation of an
apatite layer on their surface, which elicits an interfacial
biological response resulting in bioactive fixation, inhibiting further dissolution of the glass, and preventing complete resorption of the material.
Fluorine is considered one of the most effective in-vivo bone anabolic factors. In low concentrations,
fluoride ions (F(-)) increase bone mass and
mineral density, improve the resistance of the
apatite structure to
acid attack, and have well documented antibacterial properties. F(-)
ions may be incorporated into the glass in the form of
calcium fluoride (CaF2) either by part-substitution of network modifier
oxides, or by maintaining the ratios of the other constituents relatively constant.
Fluoride-containing bioactive glasses (FBGs) enhance and control osteoblast proliferation, differentiation and mineralisation. And with their ability to release
fluoride locally, FBGs make interesting candidates for various clinical applications, dentinal tubule occlusion in the treatment of
dentin hypersensitivity. This paper reviews the chemistry of FBGs and the influence of F(-) incorporation on the thermal properties, bioactivity, and cytotoxicity; and novel glass compositions for improved mechanical properties, processing, and bioactive potential.