Abstract |
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid ( Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 minutes after contrast injection. Strong correlations of the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/ cirrhosis, classified using the Ishak scoring system, were observed. The subdivisions between the grades of liver fibrosis based on RE were highly significant for all combinations, and a ROC revealed sensitivities ≥82% and specificities ≥87% for all combinations. MR imaging is a satisfactorily sensitive method for the assessment of liver fibrosis/ cirrhosis.
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Authors | Niklas Verloh, Kirsten Utpatel, Michael Haimerl, Florian Zeman, Claudia Fellner, Stefan Fichtner-Feigl, Andreas Teufel, Christian Stroszczynski, Matthias Evert, Philipp Wiggermann |
Journal | Scientific reports
(Sci Rep)
Vol. 5
Pg. 15408
(Oct 19 2015)
ISSN: 2045-2322 [Electronic] England |
PMID | 26478097
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- gadolinium ethoxybenzyl DTPA
- Gadolinium DTPA
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Topics |
- Adult
- Aged
- Biopsy
- Contrast Media
- Female
- Gadolinium DTPA
- Humans
- Image Enhancement
- Image Processing, Computer-Assisted
- Liver Cirrhosis
(diagnosis, pathology, surgery)
- Magnetic Resonance Imaging
(methods, standards)
- Male
- Middle Aged
- ROC Curve
- Risk Factors
- Severity of Illness Index
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