Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation.

Abstract

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 minutes after contrast injection. Strong correlations of the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/cirrhosis, classified using the Ishak scoring system, were observed. The subdivisions between the grades of liver fibrosis based on RE were highly significant for all combinations, and a ROC revealed sensitivities ≥82% and specificities ≥87% for all combinations. MR imaging is a satisfactorily sensitive method for the assessment of liver fibrosis/cirrhosis.

• Authors: Niklas Verloh, Kirsten Utpatel, Michael Haimerl, Florian Zeman, Claudia Fellner, Stefan Fichtner-Feigl, Andreas Teufel, Christian Stroszczynski, Matthias Evert, Philipp Wiggermann
• Journal: Scientific reports (Sci Rep) Vol. 5 Pg. 15408 (Oct 19 2015) ISSN: 2045-2322 [Electronic] England
• PMID: 26478097 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• gadolinium ethoxybenzyl DTPA
• Gadolinium DTPA

Topics

• Adult
• Aged
• Biopsy
• Contrast Media
• Female
• Gadolinium DTPA
• Humans
• Image Enhancement
• Image Processing, Computer-Assisted
• Liver Cirrhosis (diagnosis, pathology, surgery)
• Magnetic Resonance Imaging (methods, standards)
• Male
• Middle Aged
• ROC Curve
• Risk Factors
• Severity of Illness Index