Abstract | OBJECTIVE: METHODS: Patients with iRBD, patients with PD, and healthy controls were prospectively recruited to undergo colonic biopsies for comparison of α- synuclein immunoreactivity patterns between the groups by using 2 different antibodies. RESULTS: There was no difference in colonic mucosal and submucosal immunostaining between groups using the 15G7 α- synuclein antibody, which was found in almost all participants enrolled in this study. By contrast, immunostaining for serine 129-phosphorylated α- synuclein (pSyn) in submucosal nerve fibers or ganglia was found in none of 14 controls but was observed in 4 of 17 participants with iRBD and 1 out of 19 patients with PD. CONCLUSIONS: The present findings of pSyn immunostaining of colonic biopsies in a substantial proportion of iRBD participants raise the possibility that this tissue marker may be a suitable candidate to study further as a prodromal PD marker in at-risk cohorts.
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Authors | Fabienne S Sprenger, Nadia Stefanova, Ellen Gelpi, Klaus Seppi, Judith Navarro-Otano, Felix Offner, Dolores Vilas, Francesc Valldeoriola, Claustre Pont-Sunyer, Iban Aldecoa, Carles Gaig, Angels Gines, Miriam Cuatrecasas, Birgit Högl, Birgit Frauscher, Alex Iranzo, Gregor K Wenning, Wolfgang Vogel, Eduardo Tolosa, Werner Poewe |
Journal | Neurology
(Neurology)
Vol. 85
Issue 20
Pg. 1761-8
(Nov 17 2015)
ISSN: 1526-632X [Electronic] United States |
PMID | 26475692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Academy of Neurology. |
Chemical References |
- Biomarkers
- alpha-Synuclein
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Topics |
- Aged
- Biomarkers
(analysis)
- Colon
(chemistry, innervation, pathology)
- Enteric Nervous System
(chemistry, pathology)
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- REM Sleep Behavior Disorder
(diagnosis, metabolism)
- Submucous Plexus
(chemistry, pathology)
- alpha-Synuclein
(analysis)
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