Intravitreal Dexamethasone Implant for Treatment of Refractory Behçet Posterior Uveitis: One-year Follow-up Results.

Abstract

PURPOSE:

To investigate the results of dexamethasone (DEX) implant in the treatment of eyes with refractory Behçet posterior uveitis.

METHODS:

A total of 17 eyes of 12 patients with active Behçet posterior uveitis were enrolled in the study. A single intravitreal injection of DEX implant was applied to each eye. Best corrected visual acuity (BCVA), central macular thickness (CMT), vitreous haze score, and intraocular pressure (IOP) were determined, at baseline and control visits of months 1, 3, 6, and 12.

RESULTS:

The mean BCVA was significantly increased from baseline at each control visit (all p < 0.05). The mean CMT and vitreous haze score were significantly decreased from baseline at each control visit (all p < 0.05). Three eyes showed IOP spikes requiring topical anti-glaucomatous treatment.

CONCLUSIONS:

A single injection of DEX implant was safe and effective, as an additional treatment to systemic immunomodulatory drugs, in the treatment of refractory Behçet posterior uveitis, for a 6-month period.

• Authors: Erol Coşkun, Pelin Celemler, Gezmis Kimyon, Veysi Öner, Bunyamin Kisacik, Ibrahim Erbagci, Ahmet Mesut Onat
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 23 Issue 6 Pg. 437-43 ( 2015) ISSN: 1744-5078 [Electronic] England
• PMID: 26470764 (Publication Type: Journal Article)

Chemical References

• Drug Implants
• Glucocorticoids
• Dexamethasone

Topics

• Adult
• Behcet Syndrome (complications, diagnosis, drug therapy)
• Dexamethasone (administration & dosage)
• Drug Implants
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Glucocorticoids (administration & dosage)
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Time Factors
• Tomography, Optical Coherence
• Treatment Outcome
• Uveitis, Posterior (diagnosis, drug therapy, etiology)
• Visual Acuity
• Vitreous Body
• Young Adult