[Complete Response in Far-Advanced Esophageal Cancer Treated with Induction Chemotherapy Followed by Definitive Chemoradiotherapy].

Abstract

We report a case of far-advanced esophageal cancer in which induction chemotherapy followed by chemoradiotherapy achieved complete remission. A 61-year-old female presented to our hospital with dyspnea and hoarseness. CT revealed a tumor at the cervical esophagus invading and narrowing the trachea, a bulky metastasis at the right paraesophageal node, and nodal metastases at levels II and III of the left neck. No finding indicated other distant metastases. According to findings of CT and endoscopy, she was diagnosed with unresectable cancer at the cervical esophagus(cT4bN1M1[LYM], according to UICC-TNM 7 th). After 2 courses of induction chemotherapy(DTX, CDDP, and 5-FU), the tumor's volume was remarkably reduced. Thereafter, chemoradiotherapy with CDDP, 5-FU, and 60 Gy/30 Fr was administered. After 7 months of systemic chemotherapy with paclitaxel following chemoradiotherapy, the patient was judged to have complete remission based on CT and endoscopic findings. After additional administration of S-1 for 5 months, systemic chemotherapy was ceased. The patient has survived without disease progression for 22 months following initiation of treatment. It is thought that induction chemotherapy followed by chemoradiotherapy might improve local control and survival of patients with far-advanced esophageal cancers, such as our patient.

• Authors: Takuji Kaburagi, Hiroki Harada, Wataru Koizumi, Kenichiro Aga, Hajime Watanabe, Hiroaki Seki, Nobutaka Yasui, Michio Sakata, Hidetoshi Matsumoto, Akihiko Shimada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 9 Pg. 1103-6 (Sep 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26469169 (Publication Type: Case Reports, Journal Article)

Chemical References

• Taxoids
• Docetaxel
• Cisplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemoradiotherapy
• Cisplatin (administration & dosage)
• Docetaxel
• Esophageal Neoplasms (drug therapy, pathology, therapy)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Induction Chemotherapy
• Middle Aged
• Neoplasm Staging
• Remission Induction
• Taxoids (administration & dosage)