Abstract | BACKGROUND: OBJECTIVES: MATERIAL AND METHODS: Pigs (n=16) were randomized into 2 groups: a hypothermia (HT) group (n=8, 34°C) and a normothermia (NT) group (n=8, 38°C). Hypothermia to 34°C was induced with a cold blanket at the pre-hospital stage. Traumatic HS shock was induced using multiple intestinal perforations. Pulse indicator continuous cardiac output (PiCCO) was used to monitor hemodynamic changes. Coagulation capacity was measured using thromboelastography (TEG) at baseline as well as during resuscitation periods. Survival was documented for 72 h post- trauma. RESULTS: Mortality in the hypothermic HS group was low, but there were no significant differences in mortality between the groups (mortality=2/8 HT vs. 5/8 NT, p=0.137). During hypothermia, the heart rate, extravascular lung water index (EVLWI), oxygen uptake index (VO2), and oxygen delivery index (DO2) in the HT group were significantly lower than those in the NT group. There were no significant differences between the 2 groups in the other hemodynamic indices or prothrombin time. Analyses of thromboelastometry at 34°C during hypothermia showed significant differences for reaction time (R) and alpha angle, but not for maximal amplitude (MA). CONCLUSIONS:
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Authors | Bo Zhou, Gang Wang, Nanhai Peng, Xiandi He, Xiaoxiang Guan, Yun Liu |
Journal | Advances in clinical and experimental medicine : official organ Wroclaw Medical University
(Adv Clin Exp Med)
2015 Jul-Aug
Vol. 24
Issue 4
Pg. 571-8
ISSN: 1899-5276 [Print] Poland |
PMID | 26469100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Blood Coagulation
- Blood Coagulation Tests
- Disease Models, Animal
- Emergency Medical Services
(methods)
- Female
- Fluid Therapy
- Hemodynamics
- Humans
- Hypothermia, Induced
- Recovery of Function
- Rewarming
- Shock, Hemorrhagic
(blood, diagnosis, physiopathology, therapy)
- Swine
- Time Factors
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