The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns--Experimental Study Using a Rat Model of Thermal Trauma.

Abstract

BACKGROUND:

Epigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties.

OBJECTIVES:

The purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model.

MATERIAL AND METHODS:

The study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n=18); (b) the control burn group (burns+sterile saline, n=18); and (c) the burn treatment group (burns+treatment with EGCG, n=18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 μmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days.

RESULTS:

In the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group.

CONCLUSIONS:

Based on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases.

• Authors: Mubin Hosnuter, Cenk Melikoglu, Cem Aslan, Gulcan Saglam, Recep Sutcu
• Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University (Adv Clin Exp Med) 2015 May-Jun Vol. 24 Issue 3 Pg. 409-17 ISSN: 1899-5276 [Print] Poland
• PMID: 26467128 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Protective Agents
• Tumor Necrosis Factor-alpha
• Malondialdehyde
• Catechin
• epigallocatechin gallate
• Glutathione Peroxidase
• Superoxide Dismutase

Topics

• Animals
• Antioxidants (pharmacology)
• Burns (complications, drug therapy, pathology)
• Catechin (analogs & derivatives, pharmacology)
• Disease Models, Animal
• Glutathione Peroxidase (metabolism)
• Kidney (drug effects, metabolism)
• Kidney Diseases (etiology, metabolism, prevention & control)
• Lung (drug effects, metabolism)
• Lung Injury (etiology, metabolism, prevention & control)
• Malondialdehyde (metabolism)
• Protective Agents (pharmacology)
• Rats, Wistar
• Severity of Illness Index
• Skin (pathology)
• Superoxide Dismutase (metabolism)
• Time Factors
• Tumor Necrosis Factor-alpha (metabolism)