[Short-term efficacies of intravenous glucocorticoid therapy for moderate-to-severe Graves' ophthalmopathy].

Abstract

OBJECTIVE:

To evaluate the outcomes of intravenous glucocorticoid therapy with or without orbital radiotherapy for moderate-to-severe Graves' ophthalmopathy.

METHODS:

A total of 83 patients with moderate-to-severe Graves' ophthalmopathy were retrospectively analyzed. Intravenous glucocorticoid was given to patients for 3 consecutive days every four weeks in 1-3 circles. The regimens included intravenous glucocorticoid alone (n = 36) and intravenous glucocorticoid plus orbital radiotherapy (n = 47). Photophobia, lacrimation, eye pain, soft tissue congestion, edema, exophthalmos and diplopia were compared before and after treatment. The symptoms and efficacies were compared between two groups.

RESULTS:

During a 12-week follow-up, clinical activity score (CAS), exophthalmos and diplopia all improved after treatment (P < 0.05). However, the changes of CAS, exophthalmos or diplopia showed no inter-group differences (P > 0.05). The overall clinical response was 50% in glucocorticoid group and 63.8% in glucocorticoid plus orbital radiotherapy group. And there was no statistical difference (P > 0.05).

CONCLUSION:

Moderate-to-severe Graves' ophthalmopathy may be relieved by pulsed intravenous glucocorticoid with or without orbital radiotherapy. There is no inter-group difference in short-term efficacies.

• Authors: Lingling Guo, Guoqing Yang, Weijun Gu, Nan Jin, Kang Chen, Jin Du, Xianling Wang, Jinzhi Ouyang, Jingtao Dou, Jianming Ba, Zhaohui Lü, Yiming Mu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 20 Pg. 1572-5 (May 26 2015) ISSN: 0376-2491 [Print] China
• PMID: 26463604 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids

Topics

• Administration, Intravenous
• Glucocorticoids
• Graves Ophthalmopathy
• Humans
• Retrospective Studies