OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats.

Abstract

In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E‑K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E‑K19 on retinal vascular injury in AGE‑modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E‑K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases.

• Authors: Chan-Sik Kim, Junghyun Kim, Kyuhyung Jo, Yun Mi Lee, Eunjin Sohn, Nam Hee Yoo, Jin Sook Kim
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 12 Issue 5 Pg. 7279-84 (Nov 2015) ISSN: 1791-3004 [Electronic] Greece
• PMID: 26460071 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-hydroxy-3',5'-dimethoxy-1,1'-biphenyl)-3-O-glucoside
• Biphenyl Compounds
• Glucosides
• Glycation End Products, Advanced
• Plant Extracts
• Serum Albumin
• Vascular Endothelial Growth Factor A
• vascular endothelial growth factor A, rat
• Collagen
• Glycated Serum Albumin

Topics

• Animals
• Biphenyl Compounds (pharmacology, therapeutic use)
• Collagen (chemistry)
• Diabetic Retinopathy (drug therapy)
• Drug Evaluation, Preclinical
• Glucosides (pharmacology, therapeutic use)
• Glycation End Products, Advanced (physiology)
• Male
• Plant Extracts (pharmacology, therapeutic use)
• Rats, Sprague-Dawley
• Retinal Vessels (drug effects, pathology)
• Rosaceae (chemistry)
• Serum Albumin (physiology)
• Tight Junctions (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)
• Glycated Serum Albumin