Abstract | BACKGROUND: METHODS: The cachectic mice received L-carnitine (p.o.) or etomoxir (i.p.), or pioglitazone hydrochloride (p.o.) or GW9662 (i.p.). The physiological cachexia parameters, biochemical parameters, and serum cytokines were measured. The expression levels of representative molecules in the PPAR-γ signaling pathway were measured by using quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot analysis. RESULTS: CONCLUSION:
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Authors | Fang Jiang, Zongqi Zhang, Yi Zhang, Xiaohui Pan, Li Yu, Su Liu |
Journal | Oncology research and treatment
(Oncol Res Treat)
Vol. 38
Issue 10
Pg. 511-6
( 2015)
ISSN: 2296-5262 [Electronic] Switzerland |
PMID | 26452216
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 S. Karger GmbH, Freiburg. |
Chemical References |
- PPAR gamma
- Carnitine O-Palmitoyltransferase
- Carnitine
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Topics |
- Animals
- Cachexia
(drug therapy, etiology, metabolism)
- Carnitine
(administration & dosage)
- Carnitine O-Palmitoyltransferase
(metabolism)
- Colonic Neoplasms
(complications, drug therapy, metabolism)
- Dose-Response Relationship, Drug
- Mice
- PPAR gamma
(metabolism)
- Signal Transduction
(drug effects)
- Treatment Outcome
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