HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Oral Lapacho-Based Medication: An Easy, Safe, and Feasible Support to Prevent and/or Reduce Oral Mucositis During Radiotherapy for Head and Neck Cancer.

Abstract
The aim of our Phase II study is to demonstrate the benefits, safety, and tolerance of Orasol Plus, an easy and feasible Lapacho-based medication. Orasol Plus is a nutritional, swallowable solution, useful to support the defenses of the oropharyngeal mucosa. Between January and June 2014, 40 consecutive adult patients affected by head and neck cancer were enrolled. Orasol Plus was administered 3 times a day from the first day till the end of radiotherapy. Primary endpoint was to evaluate tolerance and safety of Orasol Plus; secondary endpoint was to evaluate the effect of Orasol Plus on the incidence of treatment discontinuation. Nearly all patients used Orasol Plus easily till the end of radiotherapy without interruptions. Only 11 (27.5%) patients developed oral mucositis (OM) Grade 2 and only 4 (10%) patients OM Grade 3, no patient developed OM Grade 4. No patient discontinued radiotherapy because of OM. Orasol Plus was well tolerated and the compliance of patients was optimal, mainly due to the fact that it can be swallowed. Data from our study are encouraging and they need to be confirmed by a Phase III study.
AuthorsIrene Giacomelli, Daniele Scartoni, Meacci Fiammetta, Muhammed Baki, Giacomo Zei, Cristina Muntoni, Sabrina Cappelli, Daniela Greto, Silvia Scoccianti, Lorenzo Livi
JournalNutrition and cancer (Nutr Cancer) Vol. 67 Issue 8 Pg. 1247-53 ( 2015) ISSN: 1532-7914 [Electronic] United States
PMID26451712 (Publication Type: Clinical Trial, Phase II, Journal Article)
Chemical References
  • Plant Preparations
Topics
  • Aged
  • Chemoradiotherapy (adverse effects)
  • Dietary Supplements
  • Female
  • Head and Neck Neoplasms (drug therapy, radiotherapy)
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy
  • Plant Preparations (therapeutic use)
  • Stomatitis (drug therapy, etiology, prevention & control)
  • Tabebuia

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: