Abstract | BACKGROUND: METHODS: We examined the effects of chronic ketamine in juvenile mice as well as reversal by ceftriaxone using electroencephalography (EEG). Subsequently, we assessed the effects of these treatments on markers of astrocyte proliferation, using Glial Fibrillary Acidic Protein (GFAP), and function, as evidenced by EAAT2. RESULTS: Juvenile mice exposed to chronic ketamine showed lasting alterations in EEG measurements as well as markers of astrocyte number and function. These alterations were reversed by ceftriaxone. CONCLUSIONS: Data suggest that ceftriaxone may be able to ameliorate ketamine-induced long-term disturbances in adolescent brains.
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Authors | K Dodman, R E Featherstone, J Bang, Y Liang, S J Siegel |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 156
Pg. 14-20
(Nov 01 2015)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 26442907
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anesthetics, Dissociative
- Anti-Bacterial Agents
- Excitatory Amino Acid Transporter 2
- Glial Fibrillary Acidic Protein
- Slc1a2 protein, mouse
- glial fibrillary astrocytic protein, mouse
- Ketamine
- Ceftriaxone
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Topics |
- Anesthetics, Dissociative
(pharmacology)
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Astrocytes
(drug effects)
- Brain
(cytology, drug effects)
- Ceftriaxone
(pharmacology)
- Cell Count
- Electrodes, Implanted
- Electroencephalography
(drug effects)
- Evoked Potentials
(drug effects)
- Excitatory Amino Acid Transporter 2
(genetics)
- Gamma Rhythm
(drug effects)
- Glial Fibrillary Acidic Protein
(genetics)
- Ketamine
(antagonists & inhibitors, pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
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