Abstract | BACKGROUND: Digestion of collagen with clostridial collagenase (CC) produces peptides that can induce cellular responses consistent with wound healing in vivo. However, nonhealing human wounds are typically in a state of chronic inflammation. We evaluated the effects of CC on markers of inflammation in cell culture and wound fluid from diabetic patients. METHODS: RESULTS: CONCLUSIONS: These results support a hypothesis that debridement with CCO is associated with decreased inflammation and greater progress toward healing.
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Authors | Richard C Galperin, Darrell L Lange, Sarah J Ramsay, Lei Shi, Kathy A Weedon, Nancy M Hudson, Jaime E Dickerson Jr, D Innes Cargill, Herbert B Slade |
Journal | Journal of the American Podiatric Medical Association
(J Am Podiatr Med Assoc)
Vol. 105
Issue 6
Pg. 509-19
(Nov 2015)
ISSN: 1930-8264 [Electronic] United States |
PMID | 26437320
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Cells, Cultured
- Collagenases
(therapeutic use)
- Debridement
(methods)
- Diabetic Foot
(pathology, therapy)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Prospective Studies
- Wound Healing
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