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Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis.

Abstract
Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile.
AuthorsDineo V Phatlhane, Annalise E Zemlin
JournalAnnals of hepatology (Ann Hepatol) 2015 Nov-Dec Vol. 14 Issue 6 Pg. 924-8 ISSN: 1665-2681 [Print] Mexico
PMID26436366 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-HIV Agents
  • Antitubercular Agents
  • Biomarkers
  • Lipoprotein-X
Topics
  • AIDS-Related Opportunistic Infections (complications, diagnosis, drug therapy, microbiology)
  • Anti-HIV Agents (therapeutic use)
  • Antitubercular Agents (therapeutic use)
  • Biomarkers (blood)
  • Biopsy
  • Cholestasis (blood, diagnosis, etiology)
  • Electrophoresis, Agar Gel
  • Female
  • Hepatitis (blood, diagnosis, etiology)
  • Humans
  • Hypercholesterolemia (blood, diagnosis, etiology)
  • Lipoprotein-X (blood)
  • Liver Function Tests
  • Middle Aged
  • Predictive Value of Tests
  • Risk Factors
  • Severity of Illness Index
  • Tuberculosis, Gastrointestinal (complications, diagnosis, drug therapy, microbiology)

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