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The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma.

Abstract
Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.
AuthorsNatalie Spaccarelli, Alain H Rook
JournalDermatologic clinics (Dermatol Clin) Vol. 33 Issue 4 Pg. 731-45 (Oct 2015) ISSN: 1558-0520 [Electronic] United States
PMID26433845 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Interferon-alpha
  • Retinoids
  • Interferon-beta
  • Interferon-gamma
Topics
  • Antineoplastic Agents (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
  • Combined Modality Therapy (methods)
  • Humans
  • Interferon-alpha (adverse effects, pharmacology, therapeutic use)
  • Interferon-beta (therapeutic use)
  • Interferon-gamma (adverse effects, pharmacology, therapeutic use)
  • Mycosis Fungoides (drug therapy, therapy)
  • PUVA Therapy (methods)
  • Retinoids (therapeutic use)
  • Skin Neoplasms (drug therapy, therapy)

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