HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis and Pharmacological Effects of the Anti-Cancer Agent 2-Methoxyestradiol.

Abstract
The endogenous steroid 2-methoxyestradiol (2-ME) is a metabolite of 17β-estradiol and its biosynthesis is well established. Moreover, 2-ME is also biosynthesized from estrone. For several years, 2-ME was perceived as an inactive metabolite devoid of any interesting biological activities. Since the late 1980s, a number of biological and pharmacological studies have revealed that 2-ME possesses interesting anti-cancer effects without any undesirable estrogen activity. In particular, the anti-vascular effects and anti-angiogenic activities that 2-ME exhibit, are of great interest and importance, in view of the development of new anti-cancer drugs based on 2-ME. Several clinical trial development programs have been initiated using the steroid 2-ME. In addition, based on the many pharmacological activities reported for 2-ME, but also due to the general interest in total and semi-synthesis of endogenous steroids, several research groups working with organic synthesis have prepared this steroid. Herein, the anti-cancer effects, the results from the clinical trial development programs and the synthetic studies towards 2-ME, are reviewed.
AuthorsEirik Johansson Solum, Øyvind W Akselsen, Anders Vik, Trond Vidar Hansen
JournalCurrent pharmaceutical design (Curr Pharm Des) Vol. 21 Issue 38 Pg. 5453-66 ( 2015) ISSN: 1873-4286 [Electronic] United Arab Emirates
PMID26429718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antineoplastic Agents
  • Receptors, Estrogen
  • Estradiol
  • 2-Methoxyestradiol
Topics
  • 2-Methoxyestradiol
  • Animals
  • Antineoplastic Agents (chemical synthesis, pharmacology, therapeutic use)
  • Cell Line, Tumor
  • Clinical Trials as Topic (methods)
  • Estradiol (analogs & derivatives, chemical synthesis, pharmacology, therapeutic use)
  • Humans
  • Neoplasms (drug therapy)
  • Receptors, Estrogen (antagonists & inhibitors)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: