Therapeutic potential of IL-15 in rheumatoid arthritis.

Abstract

Rheumatoid arthritis (RA) is a chronic, destructive inflammatory autoimmune disease. Cytokine-mediated immunity has been found to play an important role in the pathogenesis of autoimmune diseases including RA. Recently, much attention has been paid on the role of IL-15, which is a member of the 4 α-helix bundle cytokine family. IL-15 was detected in serum and synovial fluid from RA patients and arthritis mice models. Moreover, administration of IL-15 leads to the development of severe inflammatory arthritis, suggesting that IL-15 may be therapeutically relevant in RA. Therefore, targeting IL-15 may be significantly important and valuable. In this article, we discuss the biological features and effects of IL-15 and summarize recent advances on the pathological roles of IL-15 in RA and treatment for RA.

• Authors: Xiao-Ke Yang, Wang-Dong Xu, Rui-Xue Leng, Yan Liang, Yan-Yan Liu, Xin-Yu Fang, Chen-Chen Feng, Rui Li, Han Cen, Hai-Feng Pan, Dong-Qing Ye
• Journal: Human immunology (Hum Immunol) Vol. 76 Issue 11 Pg. 812-8 (Nov 2015) ISSN: 1879-1166 [Electronic] United States
• PMID: 26429323 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Chemical References

• Immunologic Factors
• Interleukin-15

Topics

• Animals
• Arthritis, Rheumatoid (drug therapy, etiology)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Gene Expression Regulation (drug effects)
• Humans
• Immunologic Factors (pharmacology, therapeutic use)
• Interleukin-15 (chemistry, pharmacology, physiology, therapeutic use)
• Signal Transduction (drug effects)