Abstract |
Background. Highly active antiretroviral therapy ( HAART) has contributed to reducing the occurrence of opportunistic infections and mortality in human immunodeficiency virus (HIV) infected patients. However, a paradoxical worsening of clinical signs and symptoms among patients during HAART may occur. Immune reconstitution inflammatory syndrome (IRIS) is described as a paradoxical deterioration of clinical status on initiation of HAART in patients with HIV infection. Case Report. We describe the case of a 41-year-old man with opportunistic cryptococcal encephalitis who exhibited neurological and radiological deterioration during the course of HAART. A diagnosis of central nervous system (CNS)-IRIS was based on a decrease of HIV- RNA viral load greater than 1 log, with an increase in CD4(+) T-cell count from baseline. Conclusions. Differential diagnosis of this paradoxical deterioration in clinical and neurological status from overwhelming opportunistic infection is important; it enables an avoidance of unnecessary diagnostic procedures and proper management of this HIV-associated CNS disorder.
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Authors | Ji Young Park, Min Jeong Kim |
Journal | Journal of investigative medicine high impact case reports
(J Investig Med High Impact Case Rep)
2014 Apr-Jun
Vol. 2
Issue 2
Pg. 2324709614533951
ISSN: 2324-7096 [Print] United States |
PMID | 26425608
(Publication Type: Journal Article)
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