[Predictive value of baseline plasma midregional fragment of pro-adrenomedullin level on long-term outcome of postural tachycardia syndrome children treated with midodrine hydrochloride].

Abstract

OBJECTIVE:

To explore the predictive value of baseline plasma midregional fragment of pro-adrenomedullin level (MR-proADM) on long-term survival of postural tachycardia syndrome (POTS) children treated with midodrine hydrochloride.

METHODS:

Fifty-three children (male 26, mean age (14.5 ± 4.5) years old) with POTS were included in this study, and all of them were diagnosed as POTS in our department from December 2007 to January 2010. Fifty-three children with POTS were divided into two groups according to the baseline plasma content of MR-proADM. Group I consisted of 35 POTS children with plasma content of MR-proADM > 61.5 ng/L, and the group II consisted of 18 POTS children with plasma content of MR-proADM ≤ 61.5 ng/L. The mean follow-up time was (67 ± 7) months. The orthostatic intolerance symptom score and the symptom free survival were compared between the 2 groups.

RESULTS:

At the 60 months follow-up, the symptom score of children in group I was significantly lower than that in group II (χ(2) = 4.985, P < 0.05). At 72 months follow up, the symptom score was similar between the 2 groups (χ(2) = 0.004, P > 0.05) while the symptom free survival of group I was significantly higher than that in group II (χ(2) = 4.566, P < 0.05).

CONCLUSION:

The baseline plasma MR-proADM level is value in predicting the long-term survival of POTS children treated with midodrine hydrochloride.

• Authors: Hongxia Li, Fengwen Zhang, Yuli Wang, Ping Liu, Chunyu Zhang, Xueli Feng, Junbao Du, Hongfang Jin
• Journal: Zhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 43 Issue 6 Pg. 507-10 (Jun 2015) ISSN: 0253-3758 [Print] China
• PMID: 26420118 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vasoconstrictor Agents
• Adrenomedullin
• Midodrine

Topics

• Adolescent
• Adrenomedullin
• Child
• Humans
• Male
• Midodrine (therapeutic use)
• Postural Orthostatic Tachycardia Syndrome (diagnosis, drug therapy)
• ROC Curve
• Vasoconstrictor Agents (therapeutic use)