The objective of the present study was to evaluate the possible protective effects of
Tribulus terrestris fruit aqueous extract (TTFAEt) on
lipid profile and oxidative stress in
isoproterenol (ISO) induced myocardial
necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg
body weight for 40 days orally by gavage and ISO was administered at a dose of 85 mg/kg
body weight for two consecutive days intraperitoneally at an interval of 24 h. ISO induced
myocardial infarction (MI) was confirmed by disturbances in serum
lipid profile, heart tissue lipid peroxidation and
antioxidant enzyme levels. There was a significant increase in the levels of serum total
cholesterol (32.60 %),
triglycerides (41.30 %),
very low density lipoproteins (81.81 %),
low density lipoproteins (84%) and
phospholipids (38.88 %) and a significant decrease in the levels of
high density lipoproteins (33.33 %) in the ISO control group when compared to normal controls. Additionally, there is a significant decrease in the levels of heart tissue
antioxidant enzymes such as
superoxide dismutase,
catalase,
glutathione reductase,
glutathione peroxidase and depletion of
reduced glutathione, which indicates enhanced lipid peroxidation(172 %). Pretreatment with extract significantly showed a protective effect against ISO altered
lipid profile, lipid peroxidation and
antioxidant enzyme levels. The present study showed
therapeutic effect of TTFAEt on
lipid profile and oxidative stress in
isoproterenol (ISO) induced myocardial
necrosis in experimental rats.