Influence of Polymorphism (-G308A) TNF-α on the Periportal Fibrosis Regression of Schistosomiasis After Specific Treatment.

Abstract

AIMS:

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine and important mediator of severity for periportal fibrosis (PPF). We hypothesized that the (-G380A) polymorphism in the TNF-α gene is associated with regression of PPF after treatment for schistosomiasis mansoni.

METHODS:

This is a retrospective cohort study, involving 124 Brazilian patients infected with Schistosoma mansoni, who were followed for 2 years after treatment to estimate the likelihood of PPF regression. Sociodemographic and clinical factors were also identified, with emphasis on specific treatment.

RESULTS:

No statistical difference was observed between sociodemographic and clinical factors among the exposed groups. Genotypes (-308) GA/AA were positively associated with the degree of PFF regression (relative risk [RR] = 0.52; ρ = 0.025), as well as in the image pattern of PPF (RR = 0.56; ρ = 0.048), when compared with the genotype (-308) GG. There was no statistical difference in TNF-α serum levels between the exposed groups.

CONCLUSIONS:

These results suggest that the (-G308A) polymorphism of the TNF-α gene may be one of the factors that prevents the regression of the degree and pattern of PPF in the Brazilian population, and thus it may potentially be a predictive factor of PPF intensity in schistosomiasis.

• Authors: Juliana B Oliveira, Paula C V Silva, Leticia M Vasconcelos, Adriana V Gomes, Maria Rosãngela C D Coêlho, Georgea G O M Cahu, Maria Tereza Cartaxo Muniz, Ana Lúcia C Domingues
• Journal: Genetic testing and molecular biomarkers (Genet Test Mol Biomarkers) Vol. 19 Issue 11 Pg. 598-603 (Nov 2015) ISSN: 1945-0257 [Electronic] United States
• PMID: 26406299 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tumor Necrosis Factor-alpha

Topics

• Aged
• Animals
• Cohort Studies
• Fibrosis
• Genotype
• Humans
• Liver Diseases (blood, genetics, parasitology, therapy)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Retrospective Studies
• Risk Factors
• Schistosoma mansoni (isolation & purification)
• Schistosomiasis (blood, genetics, pathology, therapy)
• Tumor Necrosis Factor-alpha (blood, genetics)