Abstract | RATIONALE:
Pain-related anxiety and depression are well known to be comorbid with chronic pain and adversely affect patient quality of life. Recent studies have shown that anxiety-like behaviors also develop with acute surgical pain, but the effects of general anesthetics on acute pain-related anxiety are unknown. OBJECTIVE: METHODS: RESULTS: Anxiety-like behaviors were observed at 24 and 72 h post- formalin injection. Concomitantly, p-ERK 1/2 expression was upregulated in the ACC at 1 and 24 h post- formalin injection. While all three general anesthetics effectively blocked nociceptive responses and activation of ERK in the rat ACC following formalin injection during anesthesia, only sevoflurane inhibited ERK activation in the spinal cord and ACC at 24 h post-injection. CONCLUSIONS: This study suggests that sevoflurane, but not intravenous anesthetics, inhibits pain-related anxiety, along with ERK activation in the ACC, probably through inhibition of spinal nociceptive transmission. Intraoperative application of inhaled anesthetics may be a better choice to reduce postoperative anxiety.
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Authors | Cong Luo, Yan-Ling Zhang, Wei Luo, Fiona H Zhou, Chang-Qi Li, Jun-Mei Xu, Ru-Ping Dai |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 232
Issue 24
Pg. 4433-44
(Dec 2015)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 26400403
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Formaldehyde
- Sevoflurane
- Extracellular Signal-Regulated MAP Kinases
- Pentobarbital
- Propofol
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Topics |
- Anesthetics, Inhalation
- Animals
- Anxiety
(metabolism)
- Behavior, Animal
(drug effects)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Formaldehyde
- Gyrus Cinguli
(metabolism)
- Male
- Methyl Ethers
(pharmacology)
- Pain
(chemically induced, metabolism)
- Pain Measurement
- Pentobarbital
(pharmacology)
- Propofol
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Sevoflurane
- Spinal Cord
(drug effects, metabolism)
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