Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma.

Abstract

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not. By conditional regression analysis, we detected a statistically significantly increased risk of osteosarcoma in patients with the AA genotype (OR = 1.97; 95%CI = 1.02-3.83) and the CA+AA genotype (OR = 1.57; 95%CI = 1.01-2.44) of -2578C/A when compared with CC genotype. Therefore, our study showed that the AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population.

• Authors: H F Zhang, J P Yan, Y S Zhuang, G Q Han
• Journal: Genetics and molecular research : GMR (Genet Mol Res) Vol. 14 Issue 3 Pg. 10524-9 (Sep 08 2015) ISSN: 1676-5680 [Electronic] Brazil
• PMID: 26400284 (Publication Type: Journal Article)

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Adolescent
• Adult
• Alleles
• Asian People
• Bone Neoplasms (ethnology, genetics, pathology)
• Case-Control Studies
• Child
• Female
• Gene Expression
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Odds Ratio
• Osteosarcoma (ethnology, genetics, pathology)
• Polymorphism, Single Nucleotide
• Regression Analysis
• Risk
• Vascular Endothelial Growth Factor A (genetics)