Abstract | BACKGROUND: METHODS: RESULTS:
5-HT6 receptor antagonists attenuated the cognitive deficits in neuropathic rats. Neuropathic rats co-treated with 5-HT6 receptor antagonist and gabapentinoids showed improvement in memory. 5-HT6 receptor antagonists enhanced the analgesic effects of gabapentinoids but had no effect on the motor side effects. The observed effects may not be due to pharmacokinetic interactions. CONCLUSIONS:
5-HT6 receptor antagonist attenuate the cognitive deficits associated with neuropathy, and this effect is also seen when co-treated with gabapentinoids. Since, 5-HT6 antagonists improved the effectiveness of gabapentinoids, reduction in the dosage and frequency of gabapentinoids treatment may reduce the side effects. Combining 5-HT6 receptor antagonist with gabapentinoids may offer a novel treatment strategy for neuropathic pain.
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Authors | Pradeep Jayarajan, Ramakrishna Nirogi, Anil Shinde, Venkatesh Goura, Vuyyuru Arun Babu, Sumanth Yathavakilla, Gopinadh Bhyrapuneni |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
Vol. 67
Issue 5
Pg. 934-42
(Oct 2015)
ISSN: 2299-5684 [Electronic] Switzerland |
PMID | 26398388
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
Chemical References |
- Amines
- Cyclohexanecarboxylic Acids
- Excitatory Amino Acid Antagonists
- Receptors, Serotonin
- Serotonin Antagonists
- serotonin 6 receptor
- Pregabalin
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Amines
(adverse effects, therapeutic use)
- Animals
- Cognition
(drug effects)
- Cyclohexanecarboxylic Acids
(adverse effects, therapeutic use)
- Excitatory Amino Acid Antagonists
(adverse effects, therapeutic use)
- Gabapentin
- Male
- Memory Disorders
(drug therapy, etiology, psychology)
- Neuralgia
(complications, psychology)
- Pregabalin
(adverse effects, therapeutic use)
- Rats
- Rats, Wistar
- Receptors, Serotonin
(drug effects)
- Serotonin Antagonists
(therapeutic use)
- gamma-Aminobutyric Acid
(adverse effects, therapeutic use)
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