HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays.

Abstract
Arsenic is a well-known toxic substance on the living organisms. However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. In the present study, effects of As2O3 (arsenic trioxide) on LTR retrotransposon polymorphism and DNA methylation as well as DNA damage in Zea mays seedlings were investigated. The results showed that all of arsenic doses caused a decreasing genomic template stability (GTS) and an increasing Random Amplified Polymorphic DNAs (RAPDs) profile changes (DNA damage). In addition, increasing DNA methylation and LTR retrotransposon polymorphism characterized a model to explain the epigenetically changes in the gene expression were also found. The results of this experiment have clearly shown that arsenic has epigenetic effect as well as its genotoxic effect. Especially, the increasing of polymorphism of some LTR retrotransposon under arsenic stress may be a part of the defense system against the stress.
AuthorsFiliz Aygun Erturk, Murat Aydin, Burcu Sigmaz, M Sinan Taspinar, Esra Arslan, Guleray Agar, Semra Yagci
JournalEnvironmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 22 Issue 23 Pg. 18601-6 (Dec 2015) ISSN: 1614-7499 [Electronic] Germany
PMID26396013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Arsenicals
  • Oxides
  • Retroelements
  • Arsenic Trioxide
Topics
  • Arsenic Trioxide
  • Arsenicals
  • DNA Methylation (drug effects)
  • Genomic Instability (drug effects)
  • Oxides (toxicity)
  • Polymorphism, Genetic (drug effects)
  • Retroelements (drug effects)
  • Seedlings (genetics)
  • Terminal Repeat Sequences (drug effects)
  • Zea mays (drug effects, genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: