Clinical efficacy of istradefylline versus rTMS on Parkinson's disease in a randomized clinical trial.

Abstract

OBJECTIVE:

To compare the efficacy of istradefylline (20 mg/day, 40 mg/day) and repetitive transcranial magnetic stimulation (rTMS) (1 Hz, 10 Hz) as an adjunct therapy to levodopa in the treatment of Parkinson's disease (PD).

METHODS:

A total of 132 PD patients from China were randomly assigned to receive 20 mg/day istradefylline plus sham-rTMS (Group I), 40 mg/day istradefylline plus sham-rTMS (Group II), placebo plus 1 Hz rTMS (Group III) and placebo plus 10 Hz rTMS (Group IV) for 12 weeks. Unified Parkinson's Disease Rating Scale (UPDRS) part III score was the primary outcome. Clinical Global Impression-Global Improvement (CGI-I) was the secondary outcome. The change in daily off time in Groups I and II was also recorded.

RESULTS:

After 12 weeks of treatment, the changes in UPDRS part III score were -6.05, -6.39, -5.91 and -6.46 for Groups I, II, III and IV, respectively, and the difference was not significant. The difference in CGI-I among the four groups was not significant. The daily off time was reduced by -1.43 hours in Group I and -1.62 hours in Group II. No severe adverse events occurred among the four groups.

CONCLUSION:

These results indicate that, as augmentation agents to levodopa in the treatment of PD, istradefylline and rTMS had comparable efficacy and tolerability.

• Authors: Zhi-jun Li, Qian Wu, Chen-ju Yi
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 31 Issue 11 Pg. 2055-8 (Nov 2015) ISSN: 1473-4877 [Electronic] England
• PMID: 26393386 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Purines
• istradefylline
• Levodopa

Topics

• Aged
• China
• Female
• Humans
• Levodopa (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Parkinson Disease (drug therapy, therapy)
• Purines (administration & dosage, therapeutic use)
• Transcranial Magnetic Stimulation (methods)
• Treatment Outcome