Eosinophilic gastroenteritis is a rare gastrointestinal (GI) disorder characterized by nonspecific GI symptoms, peripheral
eosinophilia, and eosinophilic infiltration of the intestinal wall. The disorder is classified into mucosal, muscular, and sub-serosal types, depending on the clinical picture and the depth of eosinophilic infiltration within the GI wall. Sub-serosal disease, which is complicated by
ascites, usually results in the most severe clinical form of
eosinophilic gastroenteritis and requires early
corticosteroid therapy. In such cases, a favorable outcome can be achieved after a short course of
corticosteroids. We present the case of a 28-year-old female with diffuse
abdominal pain and distention for 2 weeks. Her physical examination was significant for moderate
ascites. Initial work-up demonstrated severe peripheral blood
eosinophilia, normal liver function tests, and elevated serum
immunoglobulin E (
IgE). Upper endoscopy, colonoscopy showed a thickening of the stomach and colon, and biopsies showed marked eosinophilic infiltration of the mucosa. Ascitic fluid analysis showed significant
eosinophilia. Subsequent treatment with oral
prednisone resulted in the normalization of laboratory and radiologic abnormalities 45 days after the start of the treatment. Despite its rarity,
eosinophilic gastroenteritis needs to be recognized by the clinician because the disease is treatable, and timely diagnosis and initiation of treatment could be of major importance.