Cerebrospinal fluid Aβ40 is similarly reduced in patients with Frontotemporal Lobar Degeneration and Alzheimer's Disease.

Abstract

Cerebrospinal fluid (CSF) biomarkers have been increasingly studied for dementia diagnosis, however the accuracy to distinguish between different forms of dementia is still unsatisfactory. In this study, the added value of another CSF Aβ-peptide (Aβ40), along with the core CSF markers t-Tau, p-Tau, and Aβ42, in the discrimination between two large dementia groups of Frontotemporal Lobar Degeneration (FTLD; n=107), Alzheimer's Disease (AD; n=107) and non-demented subjects (n=33) was evaluated. In FTLD, t-Tau and p-Tau were significantly increased in relation to controls, but lower than in AD, while Aβ42 was similar in FTLD and controls, but higher than in AD. Equally reduced Aβ40 levels were seen in both dementia groups, and therefore the combination of Aβ40 with core CSF biomarkers optimally discriminated FTLD and AD patients from controls. Aβ42 and t-Tau were selected as the best biomarker subset to differentiate FTLD from AD, with no added value of Aβ40 to the model. Diagnostic accuracy between FTLD and AD was still sub-optimal, with a significant percentage (23%) of FTLD patients, in particularly women, carrying an ApoE-ε4 allele, showing a CSF-AD biomarkers profile. Although CSF Aβ40 does not appear to have an additional value in the distinction between FTLD and AD, it increases the discrimination between subjects with dementia from controls. A CSF-AD biomarker profile can be seen in patients with a clinical phenotype of FTLD, reinforcing the need for autopsy confirmation.

• Authors: Inês Baldeiras, Isabel Santana, Maria João Leitão, Maria Helena Ribeiro, Rui Pascoal, Diana Duro, Raquel Lemos, Beatriz Santiago, Maria Rosário Almeida, Catarina Resende Oliveira
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 358 Issue 1-2 Pg. 308-16 (Nov 15 2015) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 26388316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Amyloid beta-Peptides
• Biomarkers
• Peptide Fragments
• amyloid beta-protein (1-40)

Topics

• Aged
• Alzheimer Disease (cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Biomarkers (cerebrospinal fluid)
• Female
• Frontotemporal Lobar Degeneration (cerebrospinal fluid)
• Humans
• Male
• Middle Aged
• Peptide Fragments (cerebrospinal fluid)
• Sensitivity and Specificity