Abstract | BACKGROUND AND AIMS: METHODS: We measured factor XI on plasma samples collected in 1993-1995 from middle-aged adults (n = 11,439), who were followed through 2012 for incident cardiovascular events. RESULTS: Over a median of 18 years of follow-up (max = 20 years), 722 participants had incident stroke events (631 ischemic and 91 hemorrhagic) and 1776 had incident coronary events. Although there were weak positive associations between factor XI and total, ischemic, cardioembolic, and nonlacunar stroke, when adjusted for demographics, further adjustment for other stroke risk factors eliminated the associations. Similarly, there was no independent association of factor XI with incident coronary heart disease events. CONCLUSION:
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Authors | Aaron R Folsom, Kristen M George, Duke Appiah |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 243
Issue 1
Pg. 181-5
(Nov 2015)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 26386215
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Atherosclerosis
(blood, epidemiology)
- Coronary Disease
(blood, epidemiology)
- Factor XI
(metabolism)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Stroke
(blood, epidemiology)
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