Abstract | BACKGROUND: METHODS: A prospective study was conducted in patients with NPC. The patients were randomized into the intervention (n = 47) and control (n = 47) groups. Patients in the control group were treated with a general skin care regimen (placebo), whereas patients in the intervention group were treated with olive oil thrice daily for 7 weeks during chemoradiotherapy and for two weeks thereafter. On a weekly basis for a total duration of 9 weeks, a blinded observer assessed the severity of dermatitis, which was graded from 0 to 4 according to the Radiation Therapy Oncology Group (RTOG) criteria and the Visual Analog Scale (VAS) score. RESULTS: Mild reactions due to radiation (grades I and II) occurred in 93.6% of the intervention group and in 72.3% of the control group. Patients in the intervention group encountered significantly less severe dermatitis during chemoradiotherapy compared with patients in the control group (P < 0.01). A multivariate analysis revealed that the use of olive oil (P < 0.01) was significantly associated with a decrease in skin injuries. CONCLUSIONS: The prophylactic use of olive oil was associated with a significant decrease in the intensity of acute dermatitis in NPC patients. The results of this trial indicate that olive oil holds promise as a safe and effective prophylactic treatment for radiodermatitis.
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Authors | Zhaoyang Cui, Mei Xin, Haiying Yin, Jiandong Zhang, Fei Han |
Journal | International journal of clinical and experimental medicine
(Int J Clin Exp Med)
Vol. 8
Issue 7
Pg. 11000-6
( 2015)
ISSN: 1940-5901 [Print] United States |
PMID | 26379896
(Publication Type: Journal Article)
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