Aplastic anemia therapy remains difficult, due to lack of effective treatment regimens. In recent years,
Huangqi injection for the adjunctive
therapy of
aplastic anemia has been reported in many clinical trials. Considering that
Huangqi injection may be a novel approach to
aplastic anemia treatment, we conducted a meta-analysis of clinical controlled trials to assess the clinical value of
Huangqi injection in the treatment of
aplastic anemia. We searched the Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Full-text Database (VIP), Wanfang Database, PubMed and EMBASE database to collect the data about the trials of
Huangqi injection combined with
androgens for treating
aplastic anemia. A total of ten studies involving 720 patients with
aplastic anemia were included in this study. The meta-analysis showed significant increases in the pool effectiveness rate, white blood cells (WBC), haematoglobin (Hb), platelets (PLT), and reticulocytes (Ret) between the experimental group versus the control group. No severe side effects were found in this study. However, the lower Jadad scores and asymmetric funnel plot degrades the validity of the meta-analysis as the clinical evidence. Therefore,
Huangqi injection may significantly enhance the efficacy of
androgens for
aplastic anemia, suggesting that the novel approach of
Chinese traditional medicine combined with Western medicine is promising. The exact outcome required confirmation with rigorously well-designed multi-center trials.