Abstract | INTRODUCTION:
Nephrolithiasis is a frequent disease observed in 1 to 20 % of the general population. This disease predominates in male patients (2:1) and is characterized by a high rate of recurrences (about 50 %). CASE REPORT: We report the case of a 45-year old male patient who experienced during about ten years recurrent bilateral renal colic episodes due to brushite lithiasis. These stones were treated with multiple extracorporeal shock wave lithotripsy sessions. A pyeloureteral junction syndrome predisposing to bulky stones formation has been put in evidence and required a pyeloplasty. After more than ten years of disease activity, a biochemical screening diagnosed primary hyperparathyroidism (PHPT). Radiological assessment identified a parathyroid gland adenoma. Successful surgical removal of this lesion was followed by resolution of the symptomatic kidney stones formation. DISCUSSION: PHPT is associated with kidney stones in about 20 % of the patients. Hypercalciuria is the main risk factor of stones formation but other predisposing factors are also probably involved. Patients carrying a polymorphism located in the coding sequence of the calcium-sensing receptor gene or in the regulatory region of this gene seem to experience an increased occurrence of urinary lithiasis. CONCLUSION: The present case stresses the importance of a metabolic assessment in all patients with recurrent nephrolithiasis, especially in case of bilateral episodes.
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Authors | I Simon, T Roumeguère, F Devuyst, F Cotton, B-N-T Tang, M Cappello, S Corbetta, M Idrissi, A Pozdzik, J Nortier |
Journal | Revue medicale de Bruxelles
(Rev Med Brux)
2015 May-Jun
Vol. 36
Issue 3
Pg. 172-6
ISSN: 0035-3639 [Print] Belgium |
Vernacular Title | Néphrolithiases récurrentes de brushite révélant une hyperparathyroïdie primaire. |
PMID | 26372980
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Calcium Phosphates
- calcium phosphate, dibasic, dihydrate
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Topics |
- Calcium Phosphates
(metabolism)
- Diagnosis, Differential
- Humans
- Hyperparathyroidism, Primary
(complications, diagnostic imaging, pathology)
- Male
- Middle Aged
- Nephrolithiasis
(complications, diagnostic imaging, metabolism, pathology)
- Radiography
- Recurrence
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