Abstract |
This prospective study aimed to elucidate the effect of phase-related quantitative parameters of contrast-enhanced ultrasound (CEUS) with perflubutane microbubble agent to assess the cellular differentiation of hepatocellular carcinoma (HCC). Intensity was analyzed in 94 lesions (19.4 ± 4.9 mm, 86 patients), 47 well-differentiated HCCs (wHCCs) and 47 moderately-differentiated HCCs (mHCCs): I(e) (early phase) = I(te) ( tumor) - I(le) (liver), I(p) (post-vascular phase) = I(tp) ( tumor) - I(lp) (liver), I(ep) = I(e) - I(p). The area under the receiver operating characteristic curve with the best cutoff value (I(e), 13.2, I(p), -4.5, I(ep), 21.3) for discriminating between wHCC and mHCC was 0.6922 for Ie, 0.7680 for Ip and 0.7925 for Iep, which indicated a significantly greater ability to differentiate between wHCC and mHCC compared with visual/qualitative assessment (early phase, 0.6170, p = 0.04; post-vascular phase, 0.6702, p = 0.01; both phases, 0.7021, p = 0.04). In conclusion, I(ep) was found to have the highest diagnostic ability, suggesting it is a promising parameter for the cellular differentiation of HCCs with CEUS.
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Authors | Takayuki Kondo, Hitoshi Maruyama, Soichiro Kiyono, Tadashi Sekimoto, Taro Shimada, Masanori Takahashi, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Akinobu Tawada, Tetsuhiro Chiba, Fumihiko Kanai, Osamu Yokosuka |
Journal | Ultrasound in medicine & biology
(Ultrasound Med Biol)
Vol. 41
Issue 12
Pg. 3079-87
(Dec 2015)
ISSN: 1879-291X [Electronic] England |
PMID | 26371403
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Contrast Media
- Fluorocarbons
- perfluorobutane
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Topics |
- Aged
- Carcinoma, Hepatocellular
(diagnostic imaging, physiopathology)
- Cell Differentiation
(physiology)
- Contrast Media
- Female
- Fluorocarbons
- Humans
- Image Enhancement
- Liver
(diagnostic imaging, physiopathology)
- Liver Neoplasms
(diagnostic imaging, physiopathology)
- Male
- Microbubbles
- Prospective Studies
- Reproducibility of Results
- Ultrasonography
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