Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Recent clinical research has confirmed existing knowledge of the efficacy and limitations of corticosteroids in the treatment of optic neuritis. Recent studies have examined the role of race, route of administration and combination of IVCS with other therapies. Current evidence continues to support high-dose IVCS as the cornerstone of treatment of acute optic neuritis. SUMMARY: High-dose IVCS are effective in hastening visual recovery in acute typical optic neuritis, but do not affect the final visual outcome. In optic neuritis patients, IVCS may delay progression to clinically definite multiple sclerosis (CDMS) at 2 years, but not at 5 or 10 years. It is reasonable to recommend high-dose IVCS for acute optic neuritis patients with significant vision loss, severe pain and/or white matter lesions on brain MRI in whom the potential for benefit outweighs the risks.
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Authors | Devin D Mackay |
Journal | Current opinion in ophthalmology
(Curr Opin Ophthalmol)
Vol. 26
Issue 6
Pg. 439-44
(Nov 2015)
ISSN: 1531-7021 [Electronic] United States |
PMID | 26367086
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Disease Progression
- Glucocorticoids
(therapeutic use)
- Humans
- Magnetic Resonance Imaging
- Multiple Sclerosis
(drug therapy)
- Optic Neuritis
(drug therapy)
- Risk Factors
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