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Challenges and key research questions for yaws eradication.

Abstract
Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in several countries, including Ghana, Vanuatu, and Papua New Guinea. Gaps in knowledge need to be addressed to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to help with the completion of baseline mapping. The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. The integration of diagnostic tests into different stages of the eradication campaign needs investigation. Finally, studies must be done to inform the optimum mass-treatment strategy for sustainable interruption of transmission.
AuthorsMichael Marks, Oriol Mitjà, Lasse S Vestergaard, Allan Pillay, Sascha Knauf, Cheng-Yen Chen, Quique Bassat, Diana L Martin, David Fegan, Fasihah Taleo, Jacob Kool, Sheila Lukehart, Paul M Emerson, Anthony W Solomon, Tun Ye, Ronald C Ballard, David C W Mabey, Kingsley B Asiedu
JournalThe Lancet. Infectious diseases (Lancet Infect Dis) Vol. 15 Issue 10 Pg. 1220-1225 (Oct 2015) ISSN: 1474-4457 [Electronic] United States
PMID26362174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Published by Elsevier Ltd.. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Azithromycin
Topics
  • Africa, Western (epidemiology)
  • Anti-Bacterial Agents (therapeutic use)
  • Asia, Southeastern (epidemiology)
  • Azithromycin (therapeutic use)
  • Diagnostic Tests, Routine (standards)
  • Disease Eradication
  • Endemic Diseases
  • Humans
  • Pacific Islands (epidemiology)
  • Topography, Medical
  • Yaws (diagnosis, drug therapy, epidemiology, prevention & control)

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