Abstract | BACKGROUND: OBJECTIVES: To analyze the guidelines used for interpreting IGRAs in determining prophylactic treatment management for latent tuberculosis (LTB) in Israel. METHODS: We analyzed the retrospective data of 367 subjects who were referred to our laboratory during the period 2007-2011 for QuantiFERON Test- Gold In Tube (QFT-GIT) tests because of suspected LTB. Demographics and clinical data were retrieved from a questionnaire at enrollment, and 166/367 (45%) were further interviewed by phone in order to complete follow-up information on prophylactic TB treatment. RESULTS: The majority of subjects (116/166, 69.9%, P (P < 0.0001) were spared prophylactic treatment subsequent to QFT-GIT testing. Subjects with negative QFT-GIT and positive tuberculin skin test (TST) results who were BCG-vaccinated had the lowest treatment rates (6/68, 8.8%, P < 0.0001). Most BCG-vaccinated subjects with positive TST and negative QFT-GIT test results received treatment with anti- tumor necrosis factor-alpha (TNFα) (17/19, 89.5%, P = 0.004). We found more negative QFT-GIT test results in subjects who were receiving anti-TNFα or steroid and other immunosuppressive treatment prior to testing (11/11, 100%, P = 0.029; 22/26, 84.6%, P = 0.06; 15/17, 88%, P = 0.06, respectively). CONCLUSIONS: Deciding on LTB prophylactic treatment in Israel is highly influenced by QFT-GIT test results. QFT-GIT findings contribute to clinical decisions, but their interpretation must also consider the patient's medical history and clinical characteristics.
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Authors | Einat Fireman-Klein, Avraham Man, Yehuda Schwartz, Elizabeth Fireman |
Journal | The Israel Medical Association journal : IMAJ
(Isr Med Assoc J)
Vol. 17
Issue 7
Pg. 405-9
(Jul 2015)
ISSN: 1565-1088 [Print] Israel |
PMID | 26357713
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BCG Vaccine
- Immunosuppressive Agents
- Tumor Necrosis Factor-alpha
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Topics |
- Adolescent
- Adult
- BCG Vaccine
(administration & dosage)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Infant
- Interferon-gamma Release Tests
(methods)
- Israel
- Latent Tuberculosis
(diagnosis, prevention & control)
- Male
- Middle Aged
- Practice Guidelines as Topic
- Retrospective Studies
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Young Adult
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