Topical Valganciclovir for the Treatment of Hypertensive Anterior Uveitis.

Abstract

PURPOSE:

To report the use of topical valganciclovir for the treatment of hypertensive anterior uveitis associated with clinical signs of cytomegalovirus (CMV) iritis.

METHODS:

A case report and review of the literature.

RESULTS:

A 37-year-old man was referred with a unilateral hypertensive anterior uveitis with keratic precipitates suggestive of CMV as the causative agent. After institution of oral valganciclovir and topical corticosteroids, the patient's ocular inflammation resolved and intraocular pressure normalized. Therapy was eventually changed from oral valganciclovir to ophthalmic 1% valganciclovir ointment, which was able to effectively control ocular inflammation and allow the patient to discontinue topical corticosteroids and antihypertensive medications. Topical application of valganciclovir did not result in clinically evident ocular surface toxicity.

CONCLUSIONS:

1% valganciclovir ointment may prove to be an effective treatment of hypertensive anterior uveitis associated with clinical signs of CMV iritis.

• Authors: Anton Delwig, Jeremy D Keenan, Todd P Margolis
• Journal: Cornea (Cornea) Vol. 34 Issue 11 Pg. 1513-5 (Nov 2015) ISSN: 1536-4798 [Electronic] United States
• PMID: 26356754 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antiviral Agents
• Ophthalmic Solutions
• Valganciclovir
• Ganciclovir

Topics

• Administration, Topical
• Adult
• Antiviral Agents (therapeutic use)
• Aqueous Humor (virology)
• Cytomegalovirus Infections (drug therapy, virology)
• Eye Infections, Viral (drug therapy, virology)
• Ganciclovir (analogs & derivatives, therapeutic use)
• Humans
• Hypertension (drug therapy, virology)
• Intraocular Pressure
• Iritis (drug therapy, virology)
• Male
• Ophthalmic Solutions
• Polymerase Chain Reaction
• Valganciclovir