Abstract | BACKGROUND: Many studies comparing different intravenous fluid types usually do not use equipotent volumes of 3:1 crystalloid: colloid ratio in such comparisons. Conflicting results emanate from such studies. This study was designed to compare the efficacy of equipotent volumes of crystalloid, colloid and combination of crystalloid/ colloid in spinal anaesthesia- induced hypotension prophylaxis. METHODOLOGY: Pregnant women scheduled for elective Caesarean section were prospectively randomized to three groups to each received either 1 500 ml of Ringers lactate, or 500 ml of 6% pentastarch or a combination of 250 ml of 6% pentastarch and 750 ml of Ringers lactate intravenous fluid preload, before spinal anaesthesia. Hemodynamic variables were monitored. RESULTS: First 10 minutes, crystalloid showed better efficacy in hypotension prophylaxis over the other regimen. In the next 30 minutes however, there were no significant differences between the groups. CONCLUSION: Crystalloids proved more effective than colloid or their combination in hypotension prophylaxis in the first 10 minutes after spinal anaesthesia.
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Authors | Idehen Hanson Osazuwa, Amadasun Ebague |
Journal | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
(Niger J Med)
2015 Apr-Jun
Vol. 24
Issue 2
Pg. 137-43
ISSN: 1115-2613 [Print] Nigeria |
PMID | 26353424
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Colloids
- Crystalloid Solutions
- Isotonic Solutions
- Rehydration Solutions
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Topics |
- Adult
- Anesthesia, Obstetrical
(adverse effects, methods)
- Anesthesia, Spinal
(adverse effects, methods)
- Cesarean Section
(methods)
- Colloids
(administration & dosage, adverse effects)
- Crystalloid Solutions
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Monitoring
- Drug Therapy, Combination
- Female
- Fluid Therapy
(methods)
- Humans
- Hypotension
(etiology, prevention & control)
- Isotonic Solutions
(administration & dosage, adverse effects)
- Pregnancy
- Rehydration Solutions
(administration & dosage, adverse effects)
- Treatment Outcome
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