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CRYSTALLOID PRELOAD SHOWS TRANSIENT SUPERIORITY OVER COLLOID, OR THEIR COMBINATION IN SPINAL ANAESTHESIA-INDUCED HYPOTENSION PROPHYLAXIS FOR CAESAREAN SECTION.

AbstractBACKGROUND:
Many studies comparing different intravenous fluid types usually do not use equipotent volumes of 3:1 crystalloid: colloid ratio in such comparisons. Conflicting results emanate from such studies. This study was designed to compare the efficacy of equipotent volumes of crystalloid, colloid and combination of crystalloid/colloid in spinal anaesthesia-induced hypotension prophylaxis.
METHODOLOGY:
Pregnant women scheduled for elective Caesarean section were prospectively randomized to three groups to each received either 1 500 ml of Ringers lactate, or 500 ml of 6% pentastarch or a combination of 250 ml of 6% pentastarch and 750 ml of Ringers lactate intravenous fluid preload, before spinal anaesthesia. Hemodynamic variables were monitored.
RESULTS:
First 10 minutes, crystalloid showed better efficacy in hypotension prophylaxis over the other regimen. In the next 30 minutes however, there were no significant differences between the groups.
CONCLUSION:
Crystalloids proved more effective than colloid or their combination in hypotension prophylaxis in the first 10 minutes after spinal anaesthesia.
AuthorsIdehen Hanson Osazuwa, Amadasun Ebague
JournalNigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria (Niger J Med) 2015 Apr-Jun Vol. 24 Issue 2 Pg. 137-43 ISSN: 1115-2613 [Print] Nigeria
PMID26353424 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Colloids
  • Isotonic Solutions
  • Rehydration Solutions
  • crystalloid solutions
Topics
  • Adult
  • Anesthesia, Obstetrical (adverse effects, methods)
  • Anesthesia, Spinal (adverse effects, methods)
  • Cesarean Section (methods)
  • Colloids (administration & dosage, adverse effects)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Monitoring
  • Drug Therapy, Combination
  • Female
  • Fluid Therapy (methods)
  • Humans
  • Hypotension (etiology, prevention & control)
  • Isotonic Solutions (administration & dosage, adverse effects)
  • Pregnancy
  • Rehydration Solutions (administration & dosage, adverse effects)
  • Treatment Outcome

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