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Recent advances from studies on the role of structural proteins in enterovirus infection.

Abstract
Enteroviruses are a large group of small nonenveloped viruses that cause common and debilitating illnesses affecting humans and animals worldwide. The capsid composed by viral structural proteins packs the RNA genome. It is becoming apparent that structural proteins of enteroviruses play versatile roles in the virus-host interaction in the viral life cycle, more than just a shell. Furthermore, structural proteins to some extent may be associated with viral virulence and pathogenesis. Better understanding the roles of structural proteins in enterovirus infection may lead to the development of potential antiviral strategies. Here, we discuss recent advances from studies on the role of structural proteins in enterovirus infection and antiviral therapeutics targeted structural proteins.
AuthorsXingjian Wen, Anchun Cheng, Mingshu Wang, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen
JournalFuture microbiology (Future Microbiol) Vol. 10 Issue 9 Pg. 1529-42 ( 2015) ISSN: 1746-0921 [Electronic] England
PMID26343779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Capsid Proteins
  • Viral Structural Proteins
Topics
  • Animals
  • Antiviral Agents (therapeutic use)
  • Capsid Proteins (physiology)
  • Enterovirus (chemistry, pathogenicity)
  • Enterovirus Infections (therapy, virology)
  • Host-Pathogen Interactions
  • Humans
  • Viral Structural Proteins (physiology)
  • Virus Replication

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