Isocitrate dehydrogenase 1 (IDH1) mutation is an important prognostic marker in
glioma. However, its downstream effect remains incompletely understood. Long non-coding RNAs (lncRNAs) are emerging as important regulators of
tumorigenesis in a number of human
malignancies, including
glioma. Here, we investigated whether and how
lncRNA expression profiles would differ between
gliomas with or without IDH1 mutation. By using our previously reported
lncRNA mining approach, we performed
lncRNA profiling in three public
glioma microarray datasets. The differential
lncRNA expression analysis was then conducted between mutant-type and wild-type IDH1
glioma samples. Comparison analysis identified 14 and 9
lncRNA probe sets that showed significantly altered expressions in astrocytic and oligodendroglial
tumors, respectively (fold change ≥ 1.5, false discovery rate ≤ 0.1). Moreover, the differential expressions of these lncRNAs could be confirmed in the independent testing sets. Functional exploration of the lncRNAs by analyzing the
lncRNA-
protein interactions revealed that these IDH1 mutation-associated lncRNAs were involved in multiple
tumor-associated cellular processes, including metabolism, cell growth and apoptosis. Our data suggest the potential roles of
lncRNA in gliomagenesis, and may help to understand the pathogenesis of
gliomas associated with IDH1 mutation.