Abstract |
Most children with immune thrombocytopenia ( ITP) will have spontaneous remission regardless of therapy, while about 20% will go on to have chronic ITP. In those children with chronic ITP who need treatment, standard therapies for acute ITP may have adverse effects that complicate their long-term use. Thus, alternative treatment options are needed for children with chronic ITP. Thrombopoietin receptor agonists (TPO-RA) have been shown to be safe and efficacious in adults with ITP, and represent a new treatment option for children with chronic ITP. One TPO-RA, eltrombopag, is now approved for children. Clinical trials in children are ongoing and data are emerging on safety and efficacy. This review will focus on the physiology of TPO-RA, their clinical use in children, as well as the long-term safety issues that need to be considered when using these agents.
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Authors | Angelica Maria Garzon, William Beau Mitchell |
Journal | Frontiers in pediatrics
(Front Pediatr)
Vol. 3
Pg. 70
( 2015)
ISSN: 2296-2360 [Print] Switzerland |
PMID | 26322297
(Publication Type: Journal Article, Review)
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