[A Case of Esophageal Neuroendocrine Carcinoma for Which Irinotecan and Cisplatin Combination Therapy Was Effective].

Abstract	A 72-year-old previously healthy man visited our hospital with complaints of hoarseness and dysphagia. Computed tomography showed wall thickening of the thoracic esophagus; invasion to the left main bronchus, aorta, and right supraclavicular lymph nodes (LNs); right recurrent nerve LNs; and cardiac LN swelling. Esophagogastroduodenoscopy revealed an elevated tumor in the middle thoracic esophagus, which was similar to a submucosal tumor and had a longitudinal ulcer at its center. Pathologicexamination showed a tumor with a high N/C ratio, and immunohistochemical staining showed the tumor was CD56 and NSE positive, with a Ki-67 index >80%. We diagnosed esophageal neuroendocrine carcinoma (NEC), cT4N3M0, Stage IVa. We started chemotherapy with irinotecan and cisplatin (IP therapy) according to a regimen for small-cell lung cancer. After 3 courses of chemotherapy, the primary lesion and the LN swelling had almost disappeared. Esophageal NEC is relatively rare disease, so there are no standard established treatments. We report a case of esophageal NEC for which IP therapy was effective with the relevant literature cited.
Authors	Fukutaro Shimamoto, Takayuki Kii, Masahiro Goto, Shin Kuwakado, Hitoshi Nishitani, Tetsuji Terazawa, Ken Asaishi, Takahiro Miyamoto, Yoshitaka Kurisu, Kazuhide Higuchi
Journal	Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 8 Pg. 993-6 (Aug 2015) ISSN: 0385-0684 [Print] Japan
PMID	26321716 (Publication Type: Case Reports, Journal Article)
Chemical References	Irinotecan Cisplatin Camptothecin
Topics	Aged Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Camptothecin (administration & dosage, analogs & derivatives) Carcinoma, Neuroendocrine (complications, drug therapy) Cisplatin (administration & dosage) Deglutition Disorders (etiology) Esophageal Neoplasms (complications, drug therapy, pathology) Humans Irinotecan Lymphatic Metastasis Male Tomography, X-Ray Computed

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