Abstract | BACKGROUND: CASE: A 22-year-old woman, with MAS, was referred for infertility with left macropolycystic ovary, hyperestrogenemia, and chronic anovulation unsuccessfully treated by controlled hyperstimulation. Once ovarian cyst punctures and cDNA analysis verified that GNAS1 mutation was restricted to the left ovary, unilateral ovariectomy was performed. It improved right ovarian function, allowed an in vitro fertilization-induced pregnancy, but revealed an unexpected borderline epithelial ovarian tumor. SUMMARY AND CONCLUSION: Several breast cancers have already been reported in young MAS patients but not a borderline epithelial ovarian tumor. In this context, we would recommend that persistent hyperestrogenemia in an adult be corrected and gynecological follow-up of the breasts, ovaries, and endometrium be implemented.
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Authors | Nicolas Chevalier, Françoise Paris, Sylvie Fontana, Jérôme Delotte, Laura Gaspari, Patricia Ferrari, Charles Sultan, Patrick Fénichel |
Journal | Journal of pediatric and adolescent gynecology
(J Pediatr Adolesc Gynecol)
Vol. 28
Issue 6
Pg. e169-72
(Dec 2015)
ISSN: 1873-4332 [Electronic] United States |
PMID | 26321108
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Diagnosis, Differential
- Estrogens
(blood)
- Female
- Fertility
- Fibrous Dysplasia, Polyostotic
(complications, surgery)
- Humans
- Infertility, Female
(etiology, surgery)
- Magnetic Resonance Imaging
- Ovarian Cysts
(diagnosis)
- Ovarian Neoplasms
(complications, diagnosis, surgery)
- Ovariectomy
(methods)
- Pregnancy
- Young Adult
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