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Effects of Physalis peruviana L on Toxicity and Lung Cancer Induction by Nicotine Derived Nitrosamine Ketone in Rats.

Abstract
Nicotine-derived nitrosamine ketone (NNK) is considered a key tobacco smoke carcinogen inducing lung tumors. Physalis peruviana L (harankash) is considered one plant with marked health benefits. This study aimed to evaluate Physalis peruviana L effect on the toxic effect of NNK induced lung cancer in the rats by using pulmonary histopathological, immunohistochemical and DNA flow cytometric analyses. Sixty adult male rats were divided into four groups, each consisting of fifteen animals. The first group received saline, the second received two successive toxic doses of NNK only while the third received two successive toxic doses of NNK with a single daily dose of Physalis peruviana L. The fourth group received a single daily dose of Physalis peruviana L only. Toxic doses of NNK induced hyperplasia and adenocarcinoma in the lung and positive immunoreactivity for Ki-67 and p53 staining with disturbance of the lung DNA content. Administration of Physalis peruviana L with NNK led to a mild pulmonary hyperplasia and weak expression of Ki-67 and p53 with an improvement in the lung DNA content. Physalis peruviana L may protect against NNK induced lung carcinogenesis due to its antioxidant and anti-proliferative effects.
AuthorsAyman El-Meghawry El-Kenawy, Said Said Elshama, Hosam-Eldin Hussein Osman
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 14 Pg. 5863-8 ( 2015) ISSN: 2476-762X [Electronic] Thailand
PMID26320464 (Publication Type: Journal Article)
Chemical References
  • Ketones
  • Nicotinic Agonists
  • Nitrosamines
  • Plant Extracts
  • Protective Agents
  • Nicotine
Topics
  • Animals
  • Body Weight (drug effects)
  • Carcinogenesis (drug effects, pathology)
  • Flow Cytometry
  • Immunoenzyme Techniques
  • Ketones (toxicity)
  • Lung Neoplasms (chemically induced, pathology, prevention & control)
  • Male
  • Nicotine (toxicity)
  • Nicotinic Agonists (toxicity)
  • Nitrosamines (toxicity)
  • Physalis (chemistry)
  • Plant Extracts (pharmacology)
  • Protective Agents (pharmacology)
  • Rats
  • Rats, Sprague-Dawley

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