Abstract |
Natural product curcumin (Cur) and H2S-releasing prodrug SH- aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) ( mPEG-PLGA) nanoparticles through a modified oil-in-water single- emulsion solvent evaporation process. The prepared SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of 122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in water, with high drug-loading capacity and stability. Intriguingly, by treating with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were observed in vitro, and activation of the mitochondrial apoptosis pathway was indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles could have potential clinical advantages for the treatment of ovarian cancer.
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Authors | Lin Zhou, Xingmei Duan, Shi Zeng, Ke Men, Xueyan Zhang, Li Yang, Xiang Li |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 10
Pg. 5205-18
( 2015)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 26316750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Polyesters
- Solvents
- methoxypolyethyleneglycol-poly(lactic-co-glycolic acid)
- Water
- Polyethylene Glycols
- Curcumin
- Aspirin
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Topics |
- Antineoplastic Agents
(administration & dosage)
- Apoptosis
(drug effects)
- Aspirin
(administration & dosage)
- Cell Line, Tumor
(drug effects)
- Curcumin
(administration & dosage)
- Drug Delivery Systems
- Female
- Humans
- Microscopy, Electron, Transmission
- Mitochondria
(drug effects)
- Nanoparticles
(chemistry)
- Ovarian Neoplasms
(pathology)
- Particle Size
- Polyesters
(chemistry)
- Polyethylene Glycols
(chemistry)
- Solvents
(chemistry)
- Water
(chemistry)
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