Abstract | OBJECTIVE: METHODS: Fifteen subjects with prior GB, six matched obese non surgical controls, and seven lean individuals were recruited. Islet hormones were measured before and after meal ingestion during hyperinsulinemic hypoglycemic clamps to minimize the direct effects of glycemia and glucose-dependent gastrointestinal hormones on insulin secretion. RESULTS: The GB subjects had less suppression of fasting β-cell secretion during the insulin clamp compared to controls. In addition, meal-induced insulin secretion increased in the GB subjects but not controls during fixed sub-basal glycemia. In contrast, the glucagon responses to hypoglycemia and meal ingestion were lower in the GB subjects than controls. CONCLUSIONS: Among subjects with GB, the response of insulin and glucagon secretion to decreasing blood glucose is blunted, but meal-induced insulin secretion is stimulated even at fixed systemic sub-basal glycemia. These findings indicate that, following GB, islet hormone secretion is altered as a result of factors beyond circulatory glucose levels.
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Authors | Marzieh Salehi, Stephen C Woods, David A D'Alessio |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 23
Issue 10
Pg. 2046-52
(Oct 2015)
ISSN: 1930-739X [Electronic] United States |
PMID | 26316298
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Obesity Society. |
Chemical References |
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Topics |
- Gastric Bypass
(adverse effects)
- Glucose
(metabolism)
- Humans
- Insulin
(blood)
- Insulin-Secreting Cells
(physiology)
- Male
- Middle Aged
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