Antiviral effect of lithium chloride on infection of cells by canine parvovirus.

Abstract

Canine parvovirus type 2 causes significant viral disease in dogs, with high morbidity, high infectivity, and high mortality. Lithium chloride is a potential antiviral drug for viruses. We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. The viral DNA and proteins of canine parvovirus were suppressed in a dose-dependent manner by lithium chloride. Further investigation verified that viral entry into cells was inhibited in a dose-dependent manner by lithium chloride. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies.

• Authors: Pei Zhou, Xinliang Fu, Zhongshan Yan, Bo Fang, San Huang, Cheng Fu, Malin Hong, Shoujun Li
• Journal: Archives of virology (Arch Virol) Vol. 160 Issue 11 Pg. 2799-805 (Nov 2015) ISSN: 1432-8798 [Electronic] Austria
• PMID: 26315688 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Lithium Chloride

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cats
• Cell Line
• Dog Diseases (virology)
• Dogs
• Lithium Chloride (pharmacology)
• Parvovirus, Canine (drug effects, physiology)
• Virus Internalization (drug effects)
• Virus Replication (drug effects)